the journal of Pharmacy Technology the journal of Pharmacy Technology
Abstracts of Back Issues
Home
Home
Back Issues
Author Information
PharmaCE
Acknowledgments
About the journal
Order Form
Customer Service
Advertising Information
Contact Information


Milnacipran: A New Treatment for Fibromyalgia Syndrome

Katherine S Hale

To request full article click here.

Objective: To review the pharmacology, efficacy, and tolerability of milnacipran, a dual serotonin-norepinephrine reuptake inhibitor (SNRI), in the treatment of symptoms of fibromyalgia syndrome and associated fibromyalgia pain.

Data Sources: English-language articles were obtained via searches of MEDLINE (1950–January 2010), EMBASE (1980–January 2010), and International Pharmaceutical Abstracts (1970–January 2010), using the key words milnacipran, fibromyalgia, serotonin-norepinephrine reuptake inhibitors, F 2207, and pain management. Bibliographies of selected articles were used to identify additional sources.

Study Selection and Data Extraction: Available published articles reporting the results of human studies of milnacipran were reviewed for inclusion in this article. Additional information regarding pharmacology, adverse events, contraindications, and precautions was obtained from the manufacturer’s prescribing information.

Data Synthesis: Milnacipran is a dual SNRI approved for the treatment of fibromyalgia symptoms and pain. Milnacipran is well absorbed upon oral administration, has limited first-pass elimination, has a short half-life, and is not metabolized by the cytochrome P450 enzyme group. Phase 3 clinical trials evaluating the efficacy of milnacipran demonstrated a 10–20% higher composite response rate compared with placebo in the treatment of fibromyalgia symptoms and associated pain when milnacipran was given in doses of 100–200 mg/day. Significant improvements in physical functioning, fatigue, cognition, and mental health were also noted. Milnacipran appears to have fewer anticholinergic, sedative, and cardiovascular adverse effects compared with other pharmacologic treatments of fibromyalgia. Nausea was the most commonly reported adverse event.

CONCLUSIONS: Milnacipran is an effective treatment for the symptoms of fibromyalgia syndrome and associated pain. Additional studies are needed to assess comparative effectiveness with that of other pharmacologic treatments of fibromyalgia syndrome, long-term efficacy, and safety.

J Pharm Technol 2010;26:129-35

ACPE Universal Activity Number:
407-000-10-053-H01-P (Pharmacists)
407-000-10-053-H01-T (Technicians)

To purchase the full CE article click here.


Harvey Whitney Books


Harvey Whitney Books

 
 

the journal of Pharmacy Technology
is published by HARVEY WHITNEY BOOKS COMPANY
8044 Montgomery Road, Suite 415, Cincinnati, OH 45236-2919
P.O. Box 42696, Cincinnati, OH 45242-0696 USA
Tel. 513/793-3555, FAX 513/793-3600
Office Hours: 9-5 E.S.T.
Contact Information
All Rights Reserved. Copyright © 1998-