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ARIPIPRAZOLE: AN ANTIPSYCHOTIC WITH A NOVEL MECHANISM OF ACTION
Amy A Lemieux, Jennifer D Goldman-Levine, and Jessica L Goren

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OBJECTIVE: To evaluate aripiprazole in the treatment of schizophrenia, including a comparison of available agents, pharmacology, pharmacokinetics, assessment of clinical trials, and adverse effects.

DATA SOURCES: A MEDLINE search (1962–March 2003) was conducted for primary and secondary sources. Search terms included OPC-14597, aripiprazole, typical antipsychotics, atypical antipsychotics, and schizophrenia. The Review and Evaluation of Clinical Data from NDA 21-436 was accessed from the FDA Web site.

STUDY SELECTION: All articles retrieved were evaluated, and the most appropriate studies were selected. Relevant poster presentations were included.

DATA SYNTHESIS: Aripiprazole is a potent partial agonist/antagonist at the dopamine D2 receptor, as well as a partial agonist at the serotonin 5-HT1A receptor and an antagonist at the 5-HT2A receptor. Clinical trials were assessed for information on dosing, side effects, and adverse drug reactions.

CONCLUSIONS: Aripiprazole appears to be superior to placebo for the treatment of schizophrenia, with a favorable adverse effect profile.

J Pharm Technol 2003;19:365-72.

ACPE Universal Program Number: 407-000-03-055-H01

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