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SEIZURES: AN UNUSUAL
COMPLICATION OF INTRAPLEURAL POVIDONE–IODINE IRRIGATION
Zaher S Azzam, Diab Farhat, Eyal Braun, and Norberto
Krivoy
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OBJECTIVE: To report a case of seizures that probably developed because of the disinfectant and antiseptic agent povidone iodine (PVI).
CASE SUMMARY: A 67-year-old healthy white man developed pleural empyema that was treated with drainage and intrapleural PVI irrigation. Within 10 minutes, complex partial seizures with secondary generalization lasting several minutes were documented. Several hours later, the patient developed a similar episode. Both events resolved spontaneously and, in 10 months of follow-up, there was no recurrence.
DISCUSSION: The adverse effects of iodine are known; however, little has been reported about seizures following the administration of PVI. This complication is thought to be due to either the osmotic and hydrophilic qualities or the presence of ionic changes and lipid solubility of PVI.
CONCLUSIONS: Intracavitary PVI should be considered in the differential diagnosis of localized and generalized seizures.
J Pharm Technol 2002;19:94-6.
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