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RENAL VASCULITIS
ASSOCIATED WITH DOXYCYCLINE
Sorel Goland, Raya
Kazarsky, Alexander Kagan, Monica Huszar, Itzhak Abend,
and Stephen DH
Malnick
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OBJECTIVE:To report a case of renal small-vessel vasculitis related to doxycycline administration.
CASE SUMMARY:A 42-year-old healthy woman was given doxycycline 100 mg/d because of a fever and a cough. Two days later, she developed a fever and rash. In addition, she deveoped acute renal failure with a creatinine concentration of 2.2 mg/dL and a glomerular filtration rate of 25 mL/min, as well as an increase in liver enzymes. No evidence was found for infectious or autoimmune etiologies. Renal biopsy showed renal small-vessel vasculitis. The patient was treated with prednisone 60 mg/d for one month. All of her symptoms resolved after three months.
CONCLUSIONS:This is a unique case of isolated renal vasculitis associated with doxycycline.
J Pharm Technol 2001;17:220-2.
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