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To request full article click here. OBJECTIVE: To compare the efficacy of alteplase with that of urokinase (UK) in restoring the patency of occluded central venous catheters in children. STUDY DESIGN: Retrospective casecontrol study at Hôpital Ste-Justine, a pediatric teaching hospital. RESULTS: 87 UK and 46 alteplase prescriptions were studied. Alteplase was effective in 93.2% of cases of occluded central venous catheters and UK in 54.5% of cases (p < 0.001). CONCLUSIONS: Alteplase was clearly superior to UK for restoring the patency of occluded central venous catheters in children. The study is limited by its retrospective design. J Pharm Technol 2001;17:95-8. To request full article click here. |
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