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EFFICACY OF UROKINASE
AND ALTEPLASE TO REOPEN OCCLUDED CENTRAL VENOUS CATHETERS IN CHILDREN
Jean-François Bussières, Roxane Therrien,
Michèle David, Jean-Pierre Leclair, and François
Harel
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OBJECTIVE: To compare the efficacy of alteplase with that of urokinase (UK) in restoring the patency of occluded central venous catheters in children.
STUDY DESIGN: Retrospective case–control study at Hôpital Ste-Justine, a pediatric teaching hospital.
RESULTS: 87 UK and 46 alteplase prescriptions were studied. Alteplase was effective in 93.2% of cases of occluded central venous catheters and UK in 54.5% of cases (p < 0.001).
CONCLUSIONS: Alteplase was clearly superior to UK for restoring the patency of occluded central venous catheters in children. The study is limited by its retrospective design.
J Pharm Technol 2001;17:95-8.
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