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EFFICACY OF
D-PENICILLAMINE IN REDUCING LEAD
CONCENTRATIONS IN CHILDREN: A PROSPECTIVE, UNCONTROLLED STUDY
Matitiahu Lifshitz and Jacov Levy
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OBJECTIVE: To evaluate the efficacy of oral D-penicillamine therapy in children with high blood lead concentrations.
DESIGN: A prospective, uncontrolled study.
METHODS AND PATIENTS: Seven children (2–16 y old; mean 8.7) with elevated blood lead concentrations but no symptoms of lead poisoning were treated with oral D-penicillamine. Lead-contaminated homemade flour was found to be the source of poisoning. Mean ± SD blood lead concentrations prior to therapy were 60.3 ± 12.9 µg/dL (range 47.8–83). Mean blood zinc protoporphyrin (ZPP) was 337.86 ± 58.55 µmol/mol hemoglobin (Hb) (range 247–394).
RESULTS: Ninety days of treatment with D-penicillamine lowered the mean blood lead concentration by 31.7% to a mean of 40.7 ± 8.6 µg/dL (range 30–53) and lowered mean ZPP blood concentrations by 40% to a mean of 201.14 ± 14 µmol/mol Hb (range 150–278). Three patients with blood lead concentrations >45 µg/mL at the end of this therapy were subsequently treated with succimer, an alternative oral chelator; the blood lead concentrations were further reduced to <45 µg/mL.
CONCLUSIONS: D-Penicillamine therapy significantly reduced blood lead concentrations but did not achieve acceptable lead and ZPP concentrations for young children. Therefore, we conclude that 90 days of D-penicillamine treatment is of limited effectiveness in young children who have high blood lead concentrations and also show symptoms of lead poisoning.
J Pharm Technol 2000;16:98-101.
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