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RETROSPECTIVE EVALUATION
OF THE LIPID-LOWERING EFFECTS OF ATORVASTATIN
Lucinda
M Buys and Kurt A Rosenkrans
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OBJECTIVE: To evaluate the lipid-lowering effects, particularly changes in high-density lipoprotein (HDL) cholesterol, associated with atorvastatin use in a typical outpatient family medicine practice.
DESIGN: Retrospective case series.
SETTING: A community-based family medicine residency program.
PATIENTS: One hundred twenty-three patients with hyperlipidemia.
INTERVENTIONS: Treatment with atorvastatin to meet National Cholesterol Education Program (Adult Treatment Program) II goals.
MAIN OUTCOME MEASURES: Fasting lipid profiles, including total cholesterol, low-density lipoprotein (LDL) cholesterol, HDL cholesterol, and triglycerides.
RESULTS: Atorvastatin lowered total cholesterol, LDL cholesterol, and triglycerides. HDL cholesterol was essentially unchanged from baseline to follow-up. In a subset of patients (~50%), HDL cholesterol decreased by 13.1%. In the remainder of patients, HDL cholesterol increased by 10.7%. The decrease of HDL cholesterol was as much as 24 mg/dL.
CONCLUSIONS: Atorvastatin is an effective agent for lowering total cholesterol, LDL cholesterol, and triglycerides. In a subset of patients, atorvastatin appeared to lower HDL cholesterol. Close monitoring of HDL cholesterol concentrations while patients are receiving atorvastatin is important.
J Pharm Technol 2000;16:89-91.
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