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FOSINOPRIL OVERDOSE IN
AN INFANT
Kimberly A Stokes, Steven L Lanski, and
Jerrold B Leikin
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OBJECTIVE: To report an accidental fosinopril overdose in an infant.
CASE SUMMARY: A 20-month-old African-American girl ingested approximately 16 mg/kg of fosinopril. Following aggressive gastric decontamination, the patient experienced an uneventful hospital course.
DISCUSSION: This appears to be the first report of accidental fosinopril ingestion in an infant. Virtually no adverse effects were noted after an ingestion that was approximately 10 times a therapeutic adult dose. It seems that fosinopril toxicity was minimal in the accidental overdose following early gastric decontamination (within 1 h of ingestion).
CONCLUSIONS: Observation of vital signs with no invasive procedures appears to be the primary treatment method following early gastric decontamination for an accidental fosinopril overdose in an infant.
J Pharm Technol 1999;15:219-20.
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