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DEVELOPMENT OF DIABETIC
KETOACIDOSIS IN AN AIDS PATIENT BEING TREATED WITH MEGESTROL ACETATE FOR
CACHEXIA
Gina E White, Allan Rodriguez, Malmood Almed Butt, and Virgil
R Lijfrock
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OBJECTIVE: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS.
CASE SUMMARY: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia.
DISCUSSION: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy.
CONCLUSIONS: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.
J Pharm Technol 1998;14:106-9.
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